Is Trazodone (Desyrel) Safe for Dogs?
Why it’s conditional
Trazodone is one of the most commonly prescribed sedatives for dogs, used for anxiety, vet visits, and post-surgery rest, so the drug itself is dog-friendly at proper doses. The problem is strength: human tablets are much larger than pet doses, and eating several pills can cause serotonin syndrome, which has been reported to progress to tremors and seizures.
How to keep your pet safe
Use only trazodone prescribed by your vet, at the prescribed dose, and store your own bottle out of reach. Never combine it with other serotonin-boosting drugs — including leftover human antidepressants — without veterinary guidance.
Warning signs to watch for
Drowsiness, wobbliness, drooling, vomiting, diarrhea; overdose: agitation, tremors, rapid breathing, fast heart rate, fever, muscle stiffness, seizures.
When to call the vet
If your dog eats your trazodone, call your veterinarian or a pet poison hotline with the tablet strength and your dog’s weight. Do not induce vomiting without professional instruction.
Common questions
My dog ate my trazodone — will he be OK?
One human tablet often causes heavy sedation; more than that risks serotonin syndrome. Call your vet or a poison hotline with the strength and your dog’s weight for a dose-based assessment.
Can I give my dog trazodone from my own prescription?
No. Never self-dose a pet — human strengths differ from veterinary doses. Ask your vet for a prescribed amount for your dog.
More medications hazards for dogs
This page is general educational information, not a substitute for professional veterinary advice. Every pet is different — if your animal ate or touched something concerning, contact your veterinarian or a pet poison hotline right away. In the US: Pet Poison Helpline (855) 764-7661, ASPCA Animal Poison Control (888) 426-4435 (fees may apply).