Is Sertraline (Zoloft) Safe for Cats?
Why it’s a problem
Cats are very sensitive to SSRIs because of their small body size and limited ability to clear certain drugs, so a single human-strength capsule can overshoot a cat’s safe exposure. Excess serotonin can drive tremors, high heart rate, fever, and seizures.
How to keep your pet safe
Store sertraline and all antidepressants in cabinets cats cannot open, and clean up dropped pills immediately. If your cat needs behavior medication, a veterinarian can prescribe cat-appropriate options.
Warning signs to watch for
Dilated pupils, agitation, vocalizing, tremors, rapid breathing, fast heart rate, vomiting, fever; severe cases: seizures, wobbliness, collapse.
When to call the vet
Contact your veterinarian or a pet poison hotline immediately — cats can deteriorate quickly after an SSRI overdose. Do not wait for symptoms to appear, and never induce vomiting without professional guidance.
Common questions
My cat swallowed one of my antidepressant pills — is that serious?
Yes — cats are small, so a single human capsule can be a dangerous dose. Call your vet or a poison hotline now rather than waiting for signs.
Can sertraline be given to cats safely?
Only under veterinary direction. Veterinarians sometimes use SSRIs in cats, but dosing is tiny, cat-specific, and requires monitoring — never share your own prescription.
More medications hazards for cats
This page is general educational information, not a substitute for professional veterinary advice. Every pet is different — if your animal ate or touched something concerning, contact your veterinarian or a pet poison hotline right away. In the US: Pet Poison Helpline (855) 764-7661, ASPCA Animal Poison Control (888) 426-4435 (fees may apply).