Is Duloxetine (Cymbalta) Safe for Cats?
Why it’s a problem
Cats metabolize duloxetine slowly, so a swallowed capsule acts as a large and prolonged overdose. Serotonin-related signs — agitation, vocalizing, tremors, racing heart, and elevated temperature — can escalate to seizures. Any known or suspected ingestion warrants immediate professional guidance.
How to keep your pet safe
Keep all human antidepressants in closed storage cats cannot open, and count capsules if a bottle is found chewed. Never self-dose a cat with any psychiatric medication — feline behavioral issues need veterinary assessment. Cat-proofing bags and nightstands prevents most exposures.
Warning signs to watch for
Vocalizing, agitation, dilated pupils, rapid heartbeat, high body temperature, tremors, wobbliness; severe cases: seizures and collapse.
When to call the vet
Call a veterinarian or pet poison hotline immediately after any suspected exposure. Describe the amount and your cat’s behavior in detail — serotonin toxicity in cats can progress quickly.
Common questions
My cat may have swallowed a Cymbalta capsule — what should I do?
Call a veterinarian or pet poison hotline immediately even if your cat seems normal. Cats process duloxetine slowly, and signs such as agitation and tremors can build over hours.
Can cats take duloxetine for anxiety?
Never use a human prescription for a cat — feline anxiety treatment should be planned and dosed by a veterinarian with feline-appropriate options.
More medications hazards for cats
This page is general educational information, not a substitute for professional veterinary advice. Every pet is different — if your animal ate or touched something concerning, contact your veterinarian or a pet poison hotline right away. In the US: Pet Poison Helpline (855) 764-7661, ASPCA Animal Poison Control (888) 426-4435 (fees may apply).